BC-3（人胸膜積液B淋巴細胞）
CBP60818
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| I. General information | |
| Synonyms: | BC-3 |
| Background: | The cells were established from pleural effusion from a human immunodeficiency virus (HIV) negative patient diagnosed with primary effusion (body cavity based) lymphoma (PEL). BC-3 is a primary effusion lymphoma cell line originated in 1995 by Leandros Arvanitakis and Ethel Cesarman. |
| Species: | Homo sapiens, human |
| Tissue: | Pleura, pleural effusion |
| Disease: | lymphoma |
| Gender: | male, 85 years, Caucasian |
| Morphology: | lymphoblast |
| Growth Mode: | suspension |
| DNA Profile: | Amelogenin: X CSF1PO: 11,12 D13S317: 11 D16S539: 12 D5S818: 11,12 D7S820: 10,12 THO1: 6,9 TPOX: 8,11 vWA: 14,18 Cobioer’s Cell Line Authentication Service |
| Culture Medium: | RPMI-1640+20%FBS We strongly suggest to purchase the complete medium from Cobioer. |
| Cryopreservation medium: | 90%FBS+10%DMSO |
| Antigen Expression: | CD30 +; CD38 +; CD45 +; CD 54 +; CD71 +; HLA-DR +; EMA + (epithelial membrane antigen); CD2 -; CD3 -; CD4 -; CD5 -, CD8 -; CD19 -; CD20 -; CD21 -; CD22 - |
| Comments: | The BC-3 cell line contains the viral genome for Kaposi's sarcoma-associated herpesvirus (KSHV, provisionally designated HHV-8). KSHV is a recently identified and partially uncharacterized virus. BC-3 cells are negative for both HIV and Epstein-Barr virus (EBV). They are also reported to be negative for herpes simplex virus 1 & 2 (HSV-1 and HSV-2) and cytomegalovirus (CMV). The BC-3 cell line allows in vitro culture of KSHV viral genomes in the absence of EBV. BC-3 has an intact KSHV genome of about 170 kb both in the cell line and in the viral isolate. The cells do not express B-cell lineage restricted antigens or kappa or lambda immunoglobulin light chains or T-cell lineage-restricted antigens. The cells do express activation antigens. For more information, please contact Cobioer (4008-750-250). |
