藥靶模型
Drug Target Model
背景
機體具有完善精密的免疫調(diào)節(jié)和免疫監(jiān)視功能,當(dāng)腫瘤細(xì)胞侵襲時,免疫系統(tǒng)可以識別腫瘤細(xì)胞表面的腫瘤特異性抗原 (Tumour-associated antigens,TAAs),激活特異性體液免疫應(yīng)答和細(xì)胞免疫應(yīng)答,清除入侵的腫瘤細(xì)胞;同時,腫瘤細(xì)胞也能夠通過多種途徑負(fù)向調(diào)節(jié)機體免疫應(yīng)答,逃逸機體免疫監(jiān)管,在腫瘤免疫治療的領(lǐng)域,從早期的細(xì)胞因子的發(fā)現(xiàn),到免疫檢查點抑制劑,單克隆抗體、雙特異性抗體的飛速發(fā)展,包括細(xì)胞治療、溶瘤病毒、腫瘤疫苗等方法的出現(xiàn),免疫療法改變了傳統(tǒng)腫瘤治療的方式,為癌癥患者提供無限可能。
TAA Mouse Model介紹
腫瘤免疫治療領(lǐng)域的研究依然火熱,針對各靶點科佰生物開發(fā)了幾百種報告基因的細(xì)胞模型,以及一百多種現(xiàn)貨人源靶點的小鼠細(xì)胞模型如下表所示,目前我們已經(jīng)在4T1/CT26/MC-38 等常見的鼠源細(xì)胞上進(jìn)行了改造,將人源的熱門免疫靶點通過基因手段,穩(wěn)定表達(dá)在細(xì)胞上。
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4T1 |
A20 |
ANA-1 |
B16-F10 |
C1498 |
CT26 |
EL4 |
EMT6 |
H22 |
Hepa 1-6 |
ID8 |
KLN205 |
LL/2 |
MC-38 |
MFC |
PANC02 |
RENCA |
RM1 |
5T4 |
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B7H3 |
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B7H4 |
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BCMA |
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CD123 |
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CD138 |
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CD19 |
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CD20 |
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CD22 |
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CD24 |
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CD30 |
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CD33 |
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CD38 |
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CD70 |
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CD73 |
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CD74 |
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CD79 |
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CDH17 |
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CDH3 |
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CDH6 |
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CEACAM5 |
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Claudin18.2 |
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Claudin9 |
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Claudin6 |
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CLEC12A |
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DDR1 |
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DLL3 |
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EGFR |
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EGFR&ERBB3 |
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ERBB2 |
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ERBB3(HER3) |
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EpCAM |
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FAP |
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FOLR1 |
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GPC3 |
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GPRC5D |
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GUCY2C |
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IL2R |
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KK-LC-1 |
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LILRB4 |
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LRRC15 |
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LY6G6D |
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MET |
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MSLN |
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MUC16 |
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Nectin4 |
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OVA |
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PDL1 |
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PSMA |
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PTK7 |
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ROR1 |
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SSTR2 |
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TF |
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TFRC |
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TROP2 |
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掃二維碼