c-Kit D816Y/BaF3
CBP73276
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產(chǎn)品描述
產(chǎn)品數(shù)據(jù)庫
| I. Introduction | |
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Cell Line Name： |
c-Kit D816Y/BaF3 |
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Host Cell: |
Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
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Application: |
Anti-proliferation assay and PD assay |
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Freeze Medium: |
90% FBS+10% DMSO |
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Complete Culture Medium: |
RPMI-1640+10%FBS |
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Mycoplasma Status: |
Negative |
| II. Background | |
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KIT D816Y lies within the tyrosine kinase domain 2 of the Kit protein (PMID: 21640708). D816Y results in constitutive phosphorylation of Kit, activation of Akt and Mapk pathways in cultured cells (PMID: 21640708, PMID: 16397263), and confers resistance to imatinib in culture (PMID: 16397263). |
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| III. Representative Data | |
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1. WB of c-Kit D816Y/BaF3
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2.Sanger of c-Kit D816Y/BaF3
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3. Anti-proliferation assay
Figure 3. CTG Proliferation Assay of BaF3 c-KIT D816Y (C1). |
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