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首頁 /藥靶模型 /GPCR靶點細胞 /Class A(Rhodopsin) /EDNRA/β-Arrestin/CHO

EDNRA/β-Arrestin/CHO

CBP71359

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I. Background

EDNRA (Endothelin Receptor Type A) is a Protein Coding gene. Diseases associated with EDNRA include Mandibulofacial Dysostosis With Alopecia and Migraine With Or Without Aura 1. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and endothelin receptor activity.

 
II. Introduction
Host Cell:

CHO

Stability: 20 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: F12K+10%FBS+5ug/ml puromycin+5ug/ml blasticidin
Mycoplasma Status: Negative
Storage: Liquid nitrogen immediately upon delivery
Application(s):

Functional assays for EDNRA

Transducer: β-Arrestin
 
Ⅲ. Description of Host Cell Line
Organism: Hamster
Tissue: Ovary
Morphology: Epithelial
Growth Properties: Adherent
 
Ⅳ. Representative Data

Figure 1. Dose response of Endothelin 1 (swine, human) in CHO-K1 EDNRA (ET1, ETA) β-Arrestin Cell Line (C17).


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