hDLL3/4T1
CBPG0122
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產(chǎn)品描述
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I. Background | |||
DLL3 基因別名 SCDO1,其編碼的蛋白 DLL3 是一種跨膜蛋白,是 Notch 受體配體 Delta/Serrate/lag2(DSL)組的成員,在胚層的分離中,影響著體細胞邊界的形成。 DLL3 基因突變會導致嚴重的體節(jié)發(fā)生異常和脊椎肋骨發(fā)育不全。DLL3 是一種高度腫瘤選 擇性的細胞表面靶點,在正常肺癌組織及癌旁組織中不表達。DLL3 在多種腫瘤中表達上 調(diào),在小細胞肺癌、乳腺癌、垂體瘤、急性髓系白血病中有促癌作用,但在肝癌 、神經(jīng)膠 質(zhì)瘤和惡性膠質(zhì)瘤中卻發(fā)揮了抑癌作用。 | |||
II. Introduction | |||
Host Cell: | 4T1 | ||
Expressed gene: | hDLL3 | ||
Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | ||
Freeze Medium: | 90% FBS+10% DMSO | ||
Culture Medium: | RPMI-1640+10%FBS+2 μg/ml puromycin | ||
Mycoplasma Testing: | Negative | ||
Storage: | Liquid nitrogen | ||
III. Description of Host Cell Line | |||
Organism: | Mouse | ||
Tissue: | Mammary gland | ||
Morphology: | Epithelial | ||
Growth Properties: | Adherent | ||
IV. Representative Data Figure 1. Recombinant hDLL3/4T1 stably expressing hDLL3. |
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