hROR1/CHO
CBPG0100
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I. Background | |
受體酪氨酸激酶樣孤兒受體(Receptor Tyrosine Kinase-like orphan receptor,ROR)是 Ⅰ型受體酪氨酸激酶(receptor tyrosine kinase,RTK)家族中的成員,是一類膜受體,主要 包括 ROR1 和 ROR2。其中 ROR1 主要通過參與細(xì)胞內(nèi)與細(xì)胞間信號(hào)傳導(dǎo),實(shí)現(xiàn)調(diào)節(jié)細(xì)胞 代謝、增殖、凋亡、分化、遷移、轉(zhuǎn)移等功能。ROR1 在正常組織中(除了原腸胚時(shí)期) 表達(dá)量較低,但 ROR1 在多種腫瘤細(xì)胞高度表達(dá),包括乳腺癌、卵巢癌、腎癌、肺腺細(xì)胞 癌、胃癌等實(shí)體瘤細(xì)胞以及某些血液腫瘤細(xì)胞。 | |
II. Introduction | |
Host Cell: | CHO |
Expressed gene: | hROR1 |
Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
Freeze Medium: | 90% FBS+10% DMSO |
Culture Medium: | F12K+10%FBS+5μg/ml puromycin |
Mycoplasma Testing: | Negative |
Storage: | Liquid nitrogen |
III. Description of Host Cell Line | |
Organism: | Hamster |
Tissue: | Ovary |
Morphology: | Epithelial |
Growth Properties: | Adherent |
IV. Representative Data | |
Figure 1. Recombinant hROR1/CHO stably expressing hROR1. |
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