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產(chǎn)品描述
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Introduction | |
Format | Genomic DNA |
Description | NRAS G12C is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). G12C has not been characterized, but can be predicted to confer a loss of function on Nras protein based on the effects of HRAS G12C and KRAS G12C, which result in a loss of response to GTPase-activating proteins, and transFormation of cultured cells (PMID: 26037647, PMID: 6092966). |
Technical Data | |
DNA Change | c.34G>T |
AA Change | p.G12C |
Mutation type | Substitution - Missense |
Zygosity | Heterozygous |
Allelic Frequency | 25.00% |
Transcript | ENST00000369535 |
Cosmic ID | COSM562 |
Chr position(GRCh37) | chr1:115258748 |
Buffer | Tris-EDTA |
Product Information | |
Intended Use | Research Use Only |
Unit Size | 1ug |
Concentration | Download for COA |
Purofication | Download for COA |
DNA electrophoresis | Download for COA |
Sanger sequencing | |
Storage | 2-8℃ |
Expiry | 36 months from the date of manufacture |